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on a novel conditional knockout mouse model with genetically deleted Keap1 in Clara cells, where such deletion led to increased expression of Nrf2 dependent genes, e.g., NQO1, GCLM, GCLC, TXNRD1, GPX2 (47)

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The age-related decrease in GH secretory burst frequency, the half-life of endogenous GH, and the daily secretory rate correlates with increasing adiposity, decreased physical performance and decreased testosterone levels (Veldhuis et al., 1997)